Gamma Glutamyl Transferase Activity (Ggt) In Albino Rats

The use of orphenadol as a wide spectrum painkiller (analgesics) has been reported to elicit some toxic effects. This research examined the hepatobiliary effect of orphenadol solution on hepatobiliary system in albino rats. Twenty male albino rats, distributed into four groups (A, B, C and D), with five rats in each group, were used in this research. Groups A, B and C were given oral treatment of 21, 42 and 84mg/kg respectively of the drug solution for seven days consecutively, while the animals in group D were kept as control. Treatment of animals with the drug sample resulted to a decrease in physical activities, body weights, and feed and water intake during the period of treatment relative to the control. Measurement of the total protein concentration in the serum of the rats did not reveal any significant difference (P>0.05) between the test and the control groups. The activity of gamma glutamyl transferase recorded in the test groups were significantly higher than the control (P<0.05). These effects of orphenadol solution on this enzyme and total protein concentration were found to be dose-dependent. The findings of this research indicate that the toxic effects or the adverse effect of orphenadol may include the hepatobiliary system.